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Patients’ clinical characteristics and high-resolution computed tomography metrics at baseline.

Journal: ERJ Open Research

Article Title: Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

doi: 10.1183/23120541.00210-2023

Figure Lengend Snippet: Patients’ clinical characteristics and high-resolution computed tomography metrics at baseline.

Article Snippet: The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.

Techniques: Computed Tomography

Forest plot for the Spearman correlation coefficient with 95% confidence intervals between forced vital capacity (FVC) and high-resolution computed tomography (HRCT) metrics at baseline. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Journal: ERJ Open Research

Article Title: Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

doi: 10.1183/23120541.00210-2023

Figure Lengend Snippet: Forest plot for the Spearman correlation coefficient with 95% confidence intervals between forced vital capacity (FVC) and high-resolution computed tomography (HRCT) metrics at baseline. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Article Snippet: The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.

Techniques: Computed Tomography

Forest plot for the Spearman correlation coefficient with 95% confidence intervals between forced vital capacity (FVC) and high-resolution computed tomography (HRCT) metrics. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Journal: ERJ Open Research

Article Title: Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

doi: 10.1183/23120541.00210-2023

Figure Lengend Snippet: Forest plot for the Spearman correlation coefficient with 95% confidence intervals between forced vital capacity (FVC) and high-resolution computed tomography (HRCT) metrics. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Article Snippet: The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.

Techniques: Computed Tomography

Scatterplot with a smooth line using a generalised additive model between baseline high-resolution computed tomography (HRCT) metrics and forced vital capacity (FVC) slope. The shaded area represents 95% confidence interval of the smooth line. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Journal: ERJ Open Research

Article Title: Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

doi: 10.1183/23120541.00210-2023

Figure Lengend Snippet: Scatterplot with a smooth line using a generalised additive model between baseline high-resolution computed tomography (HRCT) metrics and forced vital capacity (FVC) slope. The shaded area represents 95% confidence interval of the smooth line. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Article Snippet: The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.

Techniques: Computed Tomography

Adjusted R 2 of high-resolution computed tomography (HRCT) metrics in predicting forced vital capacity (FVC) slope after adjusting baseline clinical characteristics. a) Tocilizumab phase 3 in systemic sclerosis (SSc) (n=86); two patients were not included in the analysis as they did not have post-baseline measurements; b) zinpentraxin alfa phase 2 in idiopathic pulmonary fibrosis (IPF) (n=39); c) lebrikizumab phase 2 in IPF cohort A (n=38); d) lebrikizumab phase 2 in IPF cohort B (n=106). Each HRCT metric was sorted based on their adjusted R 2 level. The dashed line is the adjusted R 2 from the base model, and each dot represents the adjusted R 2 from the base model with the added HRCT metric. Base model: FVC slope ∼ baseline FVC + sex + age + height; added model: FVC slope ∼ baseline FVC + sex + age + height + HRCT. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Journal: ERJ Open Research

Article Title: Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

doi: 10.1183/23120541.00210-2023

Figure Lengend Snippet: Adjusted R 2 of high-resolution computed tomography (HRCT) metrics in predicting forced vital capacity (FVC) slope after adjusting baseline clinical characteristics. a) Tocilizumab phase 3 in systemic sclerosis (SSc) (n=86); two patients were not included in the analysis as they did not have post-baseline measurements; b) zinpentraxin alfa phase 2 in idiopathic pulmonary fibrosis (IPF) (n=39); c) lebrikizumab phase 2 in IPF cohort A (n=38); d) lebrikizumab phase 2 in IPF cohort B (n=106). Each HRCT metric was sorted based on their adjusted R 2 level. The dashed line is the adjusted R 2 from the base model, and each dot represents the adjusted R 2 from the base model with the added HRCT metric. Base model: FVC slope ∼ baseline FVC + sex + age + height; added model: FVC slope ∼ baseline FVC + sex + age + height + HRCT. qILD: quantification of interstitial lung disease; PFD: pirfenidone.

Article Snippet: The purpose of the present study was to explore the prognostic value of quantitative high-resolution computed tomography (HRCT) metrics derived by Imbio lung texture analysis (LTA) tool in predicting FVC slope.

Techniques: Computed Tomography